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Sirtuins are orthologues of yeast Sir2 protein, where SIR stands for “silent information regulator”, because in yeast, where Sir2 was first discovered, the protein silences certain genes (i.e. inhibits their expression), which results in the extension of replicative lifespan.


How Sirtuin works for Anti Aging?

Sirtuins attracted some attention of researchers when it was presumed that inducing their activity may be responsible, or at least co-responsible for lifespan-extending effects of calorie restriction.

Extending the lifespan is still controversary but recent studies have shown that Sirtuins may have a beneficial effect on health, alleviating manifestations of many diseases, including diabetes, metabolic syndrome, cardiomyopathies, non-alcoholic hepatic steatosis, hyperinsulinism-induced dyslipidemia, chronic inflammation, neurodegenerative diseases, and some types of cancer.

There are also evidences that Sirtuins decrease obesity related disorders as ageing and obesity are both characterized by a higher incidence of oxidative stress, chronic inflammation and associated metabolic disorders, which are responsible for most age-related and obesity-related diseases.

How to stimulate Sirtuin activity in the body?

Excercising like running and using the stationary bike both seem to stimulate SIRT1 levels.

Low glucose and low fat diet like while fasting could make Sirtuin 1 expression go up.

Certain foods There might have beneficial effect on Sirtuin 1 level.

  • Resveratrol (grapes, blueberries, raspberries, mulberries, peanuts…).
  • Quercetin (capers, buckwheat, red onions, kale…).
  • Berberine (goldenseal, barberry, Oregon grape, tree turmeric…).
  • Curcumin (turmeric) 
  • Fisetin (strawberries, apples, persimmons, onions, cucumbers…).


1. The role of sirtuins in aging and age-related diseases

 2. SIRT1 Regulation in Ageing and Obesity

3. SIRT1 Activation by Natural Phytochemicals: An Overview